The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

Despite the great potential of stem cells for basic research and clinical applications,
obstacles–such as their scarce availability and difficulty in controlling their fate–need to be …

At the blastocyst stage of mammalian pre-implantation development, three distinct cell
lineages have formed: trophectoderm, hypoblast (primitive endoderm) and epiblast. The …

Pluripotency manifests during mammalian development through formation of the epiblast,
founder tissue of the embryo proper. Rodent pluripotent stem cells can be considered as two …

Stem cells are essential for maintaining tissue homeostasis and mediating physiological and
pathological regeneration. Recent breakthroughs in stem cell biology have generated …

The boundaries of embryonic stem cell (ESC) research have extended considerably in
recent years in several important ways. Alongside a deeper understanding of the pluripotent …

Pluripotential stem cells from livestock offer an exciting prospect for the biotechnology
industry. Applying strategies established for the derivation of murine induced pluripotential …

Despite tremendous efforts on isolation of pluripotent equine embryonic stem (ES) cells, to
date there are few reports about successful isolation of ESCs and no report of in vivo …

Recently we have witnessed an array of studies on direct reprogramming that describe
induced inter conversion of mature cell types from higher organisms including human. While …

Cell fate reprogramming makes possible the generation of new cell types from healthy adult
cells to replace those lost or damaged in disease. Additionally, reprogramming patient cells …