Phosphorylation events during viral infections provide potential therapeutic targets

JA Keating, R Striker - Reviews in medical virology, 2012 - Wiley Online Library
For many medically relevant viruses, there is now considerable evidence that both viral and
cellular kinases play important roles in viral infection. Ultimately, these kinases, and the …

EBV-associated lymphomas in adults

M Roschewski, WH Wilson - Best practice & research Clinical haematology, 2012 - Elsevier
Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that infects most people but results in
life-threatening diseases in only a small subset. Persons who are unable to maintain the …

NF-κB as a potential therapeutic target in microbial diseases

M Vitiello, M Galdiero, E Finamore, S Galdiero… - Molecular …, 2012 - pubs.rsc.org
The failure of conventional vaccines or antimicrobials to combat newly emerging pathogens
such as new influenza viruses or antibiotic-resistant bacteria provides significant challenges …

Subversion of cytokine networks by virally encoded decoy receptors

ML Epperson, CA Lee, DH Fremont - Immunological reviews, 2012 - Wiley Online Library
During the course of evolution, viruses have captured or created a diverse array of open
reading frames, which encode for proteins that serve to evade and sabotage the host innate …

Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCγ1 and activating NFAT1-dependent RCAN1 expression

K Bala, R Bosco, S Gramolelli, DA Haas, S Kati… - 2012 - journals.plos.org
Kaposi's Sarcoma (KS), caused by Kaposi's Sarcoma Herpesvirus (KSHV), is a highly
vascularised angiogenic tumor of endothelial cells, characterized by latently KSHV-infected …

Telomeres and viruses: common themes of genome maintenance

Z Deng, Z Wang, PM Lieberman - Frontiers in oncology, 2012 - frontiersin.org
Genome maintenance mechanisms actively suppress genetic instability associated with
cancer and aging. Some viruses provoke genetic instability by subverting the host's control …

Human herpesvirus 8 interferon regulatory factor-mediated BH3-only protein inhibition via Bid BH3-B mimicry

YB Choi, G Sandford, J Nicholas - PLoS pathogens, 2012 - journals.plos.org
Viral replication efficiency is in large part governed by the ability of viruses to counteract pro-
apoptotic signals induced by infection of host cells. For HHV-8, viral interferon regulatory …

[图书][B] Tyrosine residues Y114 and Y127 of rhadinoviral oncoprotein Tip are central to STAT activation

ED Mazumder - 2012 - search.proquest.com
Herpesvirus saimiri (HVS) induziert T Zell Lymphome in Neuweltprimaten. Stämme der
Untergruppe C sind in der Lage humane T Zellen zu transformieren. Das virale Onkoprotein …

[图书][B] Functional Interactions between Chromatin-associated Proteins and Epstein-Barr virus Nuclear Antigen 1 (EBNA1)

S Wang - 2012 - search.proquest.com
Epstein-Barr virus (EBV) is a gammaherpesvirus that persistently infects more than 90% of
the human population and its latent infection is associated with several malignancies …

[PDF][PDF] The role of the herpesviral proteins LMP2A, K1, and K15 during oncogenic transformation of primary B cells

L Steinbrück - 2012 - edoc.ub.uni-muenchen.de
During our entire life microorganisms surround us. Some of them are beneficial eg intestinal
bacteria, which hinder pathogenic bacteria to colonize the gut by competing for space and …