Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development
N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …
soluble recombinant antigens by stronger protective immunogenicity associated with the …
Technologies for global health
Executive summary Availability of health technology is inversely related to health need.
Although health-care systems in high-income countries make extensive use of technology …
Although health-care systems in high-income countries make extensive use of technology …
[HTML][HTML] A phase 3 trial of RTS, S/AS01 malaria vaccine in African infants
RTS, S Clinical Trials Partnership - New England Journal of …, 2012 - Mass Medical Soc
Background The candidate malaria vaccine RTS, S/AS01 reduced episodes of both clinical
and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing …
and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing …
Design considerations for liposomal vaccines: influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens
DS Watson, AN Endsley, L Huang - Vaccine, 2012 - Elsevier
Liposomes (phospholipid bilayer vesicles) are versatile and robust delivery systems for
induction of antibody and T lymphocyte responses to associated subunit antigens. In the last …
induction of antibody and T lymphocyte responses to associated subunit antigens. In the last …
A review of malaria vaccine clinical projects based on the WHO rainbow table
L Schwartz, GV Brown, B Genton, VS Moorthy - Malaria journal, 2012 - Springer
Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS,
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …
The INDEPTH Network: filling vital gaps in global epidemiology
The International Network for the Demographic Evaluation of Populations and their Health
(INDEPTH) Network is an umbrella organization for a group of independent health research …
(INDEPTH) Network is an umbrella organization for a group of independent health research …
Profile: the KEMRI/CDC health and demographic surveillance system—Western Kenya
FO Odhiambo, KF Laserson, M Sewe… - International journal …, 2012 - academic.oup.com
Abstract The KEMRI/Centers for Disease Control and Prevention (CDC) Health and
Demographic Surveillance System (HDSS) is located in Rarieda, Siaya and Gem Districts …
Demographic Surveillance System (HDSS) is located in Rarieda, Siaya and Gem Districts …
Adjuvants for human vaccines
CR Alving, KK Peachman, M Rao, SG Reed - Current opinion in …, 2012 - Elsevier
Rational selection of individual adjuvants can often be made on the basis of innate
molecular interactions of the foreign molecules with pattern recognition receptors such as …
molecular interactions of the foreign molecules with pattern recognition receptors such as …
Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children
T Lavstsen, L Turner, F Saguti… - Proceedings of the …, 2012 - National Acad Sciences
The clinical outcome of Plasmodium falciparum infections ranges from asymptomatic
parasitemia to severe malaria syndromes associated with high mortality. The virulence of P …
parasitemia to severe malaria syndromes associated with high mortality. The virulence of P …
ChAd63-MVA–vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans
SH Sheehy, CJA Duncan, SC Elias, P Choudhary… - Molecular Therapy, 2012 - cell.com
The induction of cellular immunity, in conjunction with antibodies, may be essential for
vaccines to protect against blood-stage infection with the human malaria parasite …
vaccines to protect against blood-stage infection with the human malaria parasite …