Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of Aβ aggregates modulate neuronal survival pathways

A Cimini, B D'Angelo, S Das, R Gentile, E Benedetti… - Acta biomaterialia, 2012 - Elsevier
Oxidative stress has been found to be associated with the progression of neurodegenerative
diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium …

Preparation and characterization challenges to understanding environmental and biological impacts of ceria nanoparticles

AS Karakoti, P Munusamy, K Hostetler… - Surface and …, 2012 - Wiley Online Library
Increasingly, it is recognized that understanding and predicting nanoparticle behavior are
often limited by the reliability and reproducibility of the production methods as well as the …

High temperature decomposition of cerium precursors to form ceria nanocrystal libraries for biological applications

SS Lee, H Zhu, EQ Contreras, A Prakash… - Chemistry of …, 2012 - ACS Publications
Nanocrystalline ceria is an interesting inorganic material for biological application that can
exhibit antioxidant properties due to facile electron transfer between cerium (III) and cerium …

Distribution, elimination, and biopersistence to 90 days of a systemically introduced 30 nm ceria-engineered nanomaterial in rats

RA Yokel, TC Au, R MacPhail, SS Hardas… - Toxicological …, 2012 - academic.oup.com
Nanoceria is used as a catalyst in diesel fuel, as an abrasive in printed circuit manufacture,
and is being pursued as an antioxidant therapeutic. Our objective is to extend previous …

Real-time monitoring of superoxide accumulation and antioxidant activity in a brain slice model using an electrochemical cytochrome c biosensor

M Ganesana, JS Erlichman, S Andreescu - Free Radical Biology and …, 2012 - Elsevier
The overproduction of reactive oxygen species and the resulting damage are central to the
pathology of many diseases. The study of the temporal and spatial accumulation of reactive …

Rat brain pro-oxidant effects of peripherally administered 5 nm ceria 30 days after exposure

SS Hardas, R Sultana, G Warrier, M Dan, RL Florence… - Neurotoxicology, 2012 - Elsevier
The objective of this study was to determine the residual pro-or anti-oxidant effects in rat
brain 30 days after systemic administration of a 5nm citrate-stabilized ceria dispersion. A∼ …

Ceria-engineered nanomaterial distribution in, and clearance from, blood: size matters

M Dan, P Wu, EA Grulke, UM Graham, JM Unrine… - …, 2012 - Future Medicine
Aims: Characterize different sized ceria-engineered nanomaterial (ENM) distribution in, and
clearance from, blood (compared to the cerium ion) following intravenous infusion. Materials …

Investigations of oxidative stress effects and their mechanisms in rat brain after systemic administration of ceria engineered nanomaterials

SS Hardas - 2012 - uknowledge.uky.edu
Advancing applications of engineered nanomaterials (ENM) in various fields create the
opportunity for intended (eg drug and gene delivery) or unintended (eg occupational and …