Parvoviruses package a ssDNA genome. Both nonpathogenic and pathogenic members
exist, including those that cause fetal infections, encompassing the entire spectrum of virus …

Understanding the mechanisms of cross-species virus transmission is critical to anticipating
emerging infectious diseases. Canine parvovirus type 2 (CPV-2) emerged as a variant of a …

Viral pathogens usurp cell surface receptors to access clathrin endocytic structures, yet the
mechanisms of virus incorporation into these structures remain incompletely understood …

Parvoviruses exploit transferrin receptor type-1 (TfR) for cellular entry in carnivores, and
specific interactions are key to control of host range. We show that several key mutations …

The adaptation of viruses to new hosts is a poorly understood process likely involving a
variety of viral structures and functions that allow efficient replication and spread. Canine …

The rat parvovirus H-1PV is a promising anticancer agent given its oncosuppressive
properties and the absence of known side effects in humans. H-1PV replicates preferentially …

Endocytosis is critical for the internalization and maturation of many DNA viruses. Since all
non-enveloped DNA viruses replicate in the nucleus, they can also take advantage of …

Several laboratory techniques have been adopted for detection of canine parvovirus (CPV)
but the big question has been on their accuracy, speed, cost and availability. This study was …

Abstract Metchnikoff shared the Nobel Prize with Paul Ehrlich 'in recognition of their work in
Immunity'. The concept of immunity had preceded by just over 100 years [1], the dim …

For successful infection, viruses must solve several problems and overcome barriers that
would impede or prevent infection. Some of these barriers include finding a suitable host …