TGF-β is an immunoregulatory protein that contributes to inadequate antitumor immune
responses in cancer patients. Recent experimental data suggests that TGF-β inhibition …

An optimal control problem for cancer chemotherapy is considered that includes
immunological activity. In the objective a weighted average of several quantities that …

Cancer is a complex, multifaceted disease. Cellular systems are perturbed both during the
onset and development of cancer, and the behavioural change of tumour cells usually …

A new optimal control model of the interactions between a growing tumour and the host
immune system, along with an immunotherapy treatment strategy, is presented. The model …

In this paper a basic mathematical model is introduced to describe the dynamics of three cell
lines after allogeneic stem cell transplantation: normal host cells, leukemic host cells and …

We consider a mathematical model in the form of a system of ordinary differential equations
(ODE) for optimally administrating cancer treatments. The ODE system dynamics …

The use of combined therapies to treat cancer is common nowadays and some papers
already addressed the relative optimization problems. In particular, it is natural to have state …

An optimal control problem for combination of cancer chemotherapy with immunotherapy in
form of a boost to the immune system is considered as a multi-input optimal control problem …

Active inuiiune response i AIR i offer principles that could be successfully implemented in
defense mechanisms of computer networks of the nearest fumre: deceuualized …

An array of powerful mathematical tools can be used to identify the key underlying
components and interactions that determine the mechanics of biological systems such as …