Contribution of uric acid to cancer risk, recurrence, and mortality
MA Fini, A Elias, RJ Johnson, RM Wright - Clinical and translational …, 2012 - Springer
Two risk factors for the development and progression of cancers that are amenable to life
style modification are chronic inflammation and the metabolic syndrome. This review …
style modification are chronic inflammation and the metabolic syndrome. This review …
Oxidative stress induces an ATM‐independent senescence pathway through p38 MAPK‐mediated lamin B1 accumulation
A Barascu, C Le Chalony, G Pennarun, D Genet… - The EMBO …, 2012 - embopress.org
We report crosstalk between three senescence‐inducing conditions, DNA damage response
(DDR) defects, oxidative stress (OS) and nuclear shape alterations. The recessive …
(DDR) defects, oxidative stress (OS) and nuclear shape alterations. The recessive …
Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway
A pool of myoblasts available for myogenesis is important for skeletal muscle size. The
decreased number of skeletal muscle fibers could be due to the decreased myoblast …
decreased number of skeletal muscle fibers could be due to the decreased myoblast …
Phosphorylation of FOXO3a on Ser-7 by p38 promotes its nuclear localization in response to doxorubicin
KK Ho, VA McGuire, CY Koo, KW Muir… - Journal of Biological …, 2012 - ASBMB
FOXO3a is a forkhead transcription factor that regulates a multitude of important cellular
processes, including proliferation, apoptosis, differentiation, and metabolism. Doxorubicin …
processes, including proliferation, apoptosis, differentiation, and metabolism. Doxorubicin …
Pulmonary endothelial cell NOX
Reactive oxygen species (ROS) have profound influences on cellular homeostasis. In
excess, they can potentiate the oxidation of numerous molecules, including proteins, lipids …
excess, they can potentiate the oxidation of numerous molecules, including proteins, lipids …
Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage
S Liu, W Hou, P Yao, N Li, B Zhang, L Hao, AK Nüssler… - Toxicology in Vitro, 2012 - Elsevier
Quercetin, one of the most widely distributed flavonoids in plants, possesses strong free
radical scavenging ability and potent hepatoprotective effects. However, the protective effect …
radical scavenging ability and potent hepatoprotective effects. However, the protective effect …
Low molecular weight fucoidan from the sporophyll of Undaria pinnatifida suppresses inflammation by promoting the inhibition of mitogen-activated protein kinases …
KJ Kim, KY Yoon, BY Lee - Fitoterapia, 2012 - Elsevier
The suppression of MAPK and oxidative stress could be an important anti-inflammatory
mechanism. Fucoidan regulates MAPK activity in several cell lines. However, the …
mechanism. Fucoidan regulates MAPK activity in several cell lines. However, the …
Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 …
F Zhang, C Ni, D Kong, X Zhang, X Zhu, L Chen… - Toxicology and applied …, 2012 - Elsevier
Hepatic fibrosis represents a frequent event following chronic insult to trigger wound healing
reactions with accumulation of extracellular matrix (ECM) in the liver. Activation of hepatic …
reactions with accumulation of extracellular matrix (ECM) in the liver. Activation of hepatic …
A comparative study on invasion, survival, modulation of oxidative burst, and nitric oxide responses of macrophages (HD11), and systemic infection in chickens by …
H He, KJ Genovese, CL Swaggerty… - Foodborne …, 2012 - liebertpub.com
Poultry is a major reservoir for foodborne Salmonella serovars. Salmonella Typhimurium,
Salmonella Enteritidis, Salmonella Heidelberg, Salmonella Kentucky, and Salmonella …
Salmonella Enteritidis, Salmonella Heidelberg, Salmonella Kentucky, and Salmonella …
Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase-and p53-dependent pathways
L Li, GGL Yue, CBS Lau, H Sun, KP Fung… - Toxicology and applied …, 2012 - Elsevier
Pancreatic cancer is difficult to detect early and responds poorly to chemotherapy. A
breakthrough in the development of new therapeutic agents is urgently needed. Eriocalyxin …
breakthrough in the development of new therapeutic agents is urgently needed. Eriocalyxin …