From genome-wide association studies to disease mechanisms: celiac disease as a model for autoimmune diseases
Celiac disease is characterized by a chronic inflammatory reaction in the intestine and is
triggered by gluten, a constituent derived from grains which is present in the common daily …
triggered by gluten, a constituent derived from grains which is present in the common daily …
Complement genetics, deficiencies, and disease associations
KR Mayilyan - Protein & cell, 2012 - academic.oup.com
The complement system is a key component of innate immunity. More than 45 genes
encoding the proteins of complement components or their isotypes and subunits, receptors …
encoding the proteins of complement components or their isotypes and subunits, receptors …
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …
Genetically distinct subsets within ANCA-associated vasculitis
PA Lyons, TF Rayner, S Trivedi, JU Holle… - … England Journal of …, 2012 - Mass Medical Soc
Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits
Genome-wide association studies have identified hundreds of loci for type 2 diabetes,
coronary artery disease and myocardial infarction, as well as for related traits such as body …
coronary artery disease and myocardial infarction, as well as for related traits such as body …
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
We genotyped 2,861 cases of primary biliary cirrhosis (PBC) from the UK PBC Consortium
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …
and 8,514 UK population controls across 196,524 variants within 186 known autoimmune …
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
FW Asselbergs, Y Guo, EPA Van Iperen… - The American Journal of …, 2012 - cell.com
Genome-wide association studies (GWASs) have identified many SNPs underlying
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …
variations in plasma-lipid levels. We explore whether additional loci associated with plasma …
Common variants at the MHC locus and at chromosome 16q24. 1 predispose to Barrett's esophagus
Esophageal Adenocarcinoma Genetics Consortium… - Nature …, 2012 - nature.com
Barrett's esophagus is an increasingly common disease that is strongly associated with
reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to …
reflux of stomach acid and usually a hiatus hernia, and it strongly predisposes to …
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation
Identifying the genes that influence levels of pro-inflammatory molecules can help to
elucidate the mechanisms underlying this process. We first conducted a two-stage genome …
elucidate the mechanisms underlying this process. We first conducted a two-stage genome …