Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …

Summary p53 is critical in regulating the differentiation of ES and induced pluripotent stem
(iPS) cells. Here, we report a whole-genome study of p53-mediated DNA damage signaling …

Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …

Among the human genome, p53 is one of the first tumor suppressor genes to be discovered.
It has a wide range of functions covering cell cycle control, apoptosis, genome integrity …

In skeletal muscle, asymmetrically dividing satellite stem cells give rise to committed satellite
cells that transcribe the myogenic determination factor Myf5, a Pax7-target gene. We …

Environmental factors such as nutritional state may act on the epigenome that consequently
contributes to the metabolic adaptation of cells and the organisms. The lysine-specific …

The discovery that protein and nucleic acid demethylation is common opens up the
possibility of 'methylation cycles' of functional importance, including in the regulation of gene …

Tudor domain proteins function as molecular adaptors, binding methylated arginine or lysine
residues on their substrates to promote physical interactions and the assembly of …

There is considerable evidence suggesting that epigenetic mechanisms may mediate
development of chronic inflammation by modulating the expression of pro-inflammatory …