The glutamate neurotransmitter system is one of the major candidate pathways for the
pathophysiology of schizophrenia, and increased understanding of the pharmacology …

Since d-amino acids were identified in mammals, d-serine has been one of the most
extensively studied “unnatural amino acids”. This brain-enriched transmitter-like molecule …

Recent years have witnessed a renewed interest in the pathogenic mechanisms of
amyotrophic lateral sclerosis (ALS), a late-onset progressive degeneration of motor neurons …

A potential role for d-amino acids in motor neuron disease/amyotrophic lateral sclerosis
(ALS) is emerging. d-Serine, which is an activator/co-agonist at the N-methyl-d-aspartate …

Considering the lengthy history of pharmacological treatment of schizophrenia, the
development of novel antipsychotic agents targeting the glutamatergic system is relatively …

Kynurenic acid (KYNA), an antagonist of the α7 nicotinic acetylcholine receptor and the N-
methyl-d-aspartate receptor, and 3-hydroxykynurenine (3-HK), a generator of reactive …

J. Neurochem.(2012) 120, 1026–1035. Abstract In the mammalian brain, the α7 nicotinic
and NMDA receptor antagonist kynurenic acid is synthesized by irreversible enzymatic …

Polyriboinosinic-polyribocytidilic acid (polyI: C) is a synthetic analog that elicits viral-like
immune responses in mammals. We have recently found that polyI: C treatment in neonatal …