The epigenetic regulation of DNA-templated processes has been intensely studied over the
last 15 years. DNA methylation, histone modification, nucleosome remodeling, and RNA …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Random forests (RF) is a popular tree-based ensemble machine learning tool that is highly
data adaptive, applies to “large p, small n” problems, and is able to account for correlation as …

For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …

Current hypotheses suggest that tumors originate from cells that carry out a process of
“malignant reprogramming” driven by genetic and epigenetic alterations. Multiples studies …

Epigenetic dysregulation is being increasingly recognized as a hallmark of cancer. Post-
translational modifications of histones, in particular, are known to play important roles gene …

Oxidative stress plays an important part in the appearance and development of
cardiovascular diseases. In this context, overproduction of reactive oxygen species leads to …

Tumor-associated epigenetic alterations including DNA methylation and histone
modifications are important determinants in the initiation and progression of hepatocellular …

Fusion protein AML1-ETO, resulting from t (8; 21) translocation, is highly related to leukemia
development. It has been reported that full-length AML1-ETO blocks AML1 function and …