The identification of small subpopulations of cancer stem cells (CSCs) from blood
mononuclear cells in human acute myeloid leukemia (AML) in 1997 was a landmark …

To directly study complex human hemato-lymphoid system physiology and respective
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …

It has been hypothesized that carcinoma metastasis is initiated by a subpopulation of
circulating tumor cells (CTCs) found in the blood of patients. However, although the …

Mobilization of the T-cell response against cancer has the potential to achieve long-lasting
cures. However, it is not known how to harness antigen-presenting cells optimally to achieve …

CD47 is an antiphagocytic signal that cancer cells employ to inhibit macrophage-mediated
destruction. Here, we modified the binding domain of human SIRPα, the receptor for CD47 …

Induction treatments for acute myeloid leukemia (AML) have remained largely unchanged
for nearly 50 years, and AML remains a disease of poor prognosis. Allogeneic …

Interactions between cells and their surroundings are important for proper function and
homeostasis in a multicellular organism. These interactions can either be established …

Calreticulin is a calcium-binding chaperone that has several functions in the immune
response. In the endoplasmic reticulum (ER), calreticulin facilitates the folding of major …

Preclinical and clinical findings suggest that tumor-specific immune responses may be
responsible–at least in part–for the clinical success of therapeutic regimens that rely on …

Monocytes and tumor-associated macrophages are part of the myeloid family, a group of
hematopoietic derived cells. Monocytes are direct precursors of hematopoietic stem cell …