The role of oxidative stress in Parkinson's disease

V Dias, E Junn, MM Mouradian - Journal of Parkinson's …, 2013 - content.iospress.com
Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

The role of innate and adaptive immunity in Parkinson's disease

GT Kannarkat, JM Boss… - Journal of Parkinson's …, 2013 - content.iospress.com
In recent years, inflammation has become implicated as a major pathogenic factor in the
onset and progression of Parkinson's disease. Understanding the precise role for …

Triggering of inflammasome by aggregated α–synuclein, an inflammatory response in synucleinopathies

G Codolo, N Plotegher, T Pozzobon, M Brucale… - PloS one, 2013 - journals.plos.org
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. It is
characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta of …

Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral …

V Sanchez-Guajardo, CJ Barnum, MG Tansey… - ASN …, 2013 - journals.sagepub.com
The role of neuroinflammation and the adaptive immune system in PD (Parkinson's disease)
has been the subject of intense investigation in recent years, both in animal models of …

Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein

D Béraud, HA Hathaway, J Trecki… - Journal of Neuroimmune …, 2013 - Springer
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder typified by tremor, rigidity, akinesia and postural instability due in part to the loss of …

The role of inflammation in sporadic and familial Parkinson's disease

M Deleidi, T Gasser - Cellular and Molecular Life Sciences, 2013 - Springer
The etiology of Parkinson's disease (PD) is complex and most likely involves numerous
environmental and heritable risk factors. Interestingly, many genetic variants, which have …

α-Synuclein vaccination prevents the accumulation of parkinson disease-like pathologic inclusions in striatum in association with regulatory T cell recruitment in a rat …

V Sanchez-Guajardo, A Annibali… - … of Neuropathology & …, 2013 - academic.oup.com
Human leukocyte antigen-DR induction and lymphocyte infiltrates in the brains of patients
with Parkinson disease (PD) and the presence in serum of α-synuclein (α-syn)-specific …

PPAR-γ: therapeutic prospects in Parkinson's disease

AR Carta - Current drug targets, 2013 - ingentaconnect.com
Parkinson's disease (PD) is amongst the most frequent neurodegenerative disorders, the
main pathologic hallmark of which is the degeneration of the substantia nigra pars …

The role of glia in alpha-synucleinopathies

L Fellner, N Stefanova - Molecular neurobiology, 2013 - Springer
Abstract α-Synuclein (AS)-positive inclusions are the pathological hallmark of Parkinson's
disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), all …

Commentary: progressive inflammation as a contributing factor to early development of Parkinson's disease

S Pradhan, K Andreasson - Experimental neurology, 2013 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with three cardinal
features of pathology: 1. Aggregation of α-synuclein into intraneuronal structures called …