The last few years have seen the development of large efforts for the analysis of genome
function, especially in the context of genome variation. One of the most prominent directions …

The dominant paradigm of “one gene, one target, one disease” has influenced many
aspects of drug discovery strategy. However, in recent years, it has been appreciated that …

Longevity is regulated by a network of closely linked metabolic systems. We used a
combination of mouse population genetics and RNA interference in Caenorhabditis elegans …

Obesity is a highly heritable disease driven by complex interactions between genetic and
environmental factors. Human genome-wide association studies (GWAS) have identified a …

The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …

Purpose: To identify metabolic pathways that are perturbed in pancreatic ductal
adenocarcinoma (PDAC), we investigated gene-metabolite networks with integration of …

Genetic mapping of complex diseases to date depends on variations inside or close to the
genes that perturb their activities. A strong body of evidence suggests that changes in gene …

Germline determinants of gene expression in tumors are infrequently studied due to the
complexity of transcript regulation caused by somatically acquired alterations. We performed …

One of the challenges raised by next generation sequencing (NGS) is the identification of
clinically relevant mutations among all the genetic variation found in an individual. Network …

A more nuanced approach to drug design is to use multiple drugs in combination to target
interacting or complementary pathways. Drug combination treatments have shown higher …