Although the histological changes seen in psoriasis have long been well characterized, the
underlying cellular and molecular mechanisms have only begun to be elucidated over the …

The pathobiology of alopecia areata (AA), one of the most frequent autoimmune diseases
and a major unsolved clinical problem, has intrigued dermatologists, hair biologists and …

Atopic dermatitis (AD) is the most common dermatological disease of childhood. Many
children with AD have asthma and AD shares regions of genetic linkage with psoriasis …

Objective Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative
colitis (UC), shares clinical and immunological features with psoriasis. Genome-wide …

Genetic epidemiological studies have demonstrated a significant genetic basis to both
psoriasis and psoriatic arthritis (PsA). Although candidate gene association studies had …

Psoriasis is a chronic inflammatory disease of the skin. The causes of psoriasis are
unknown, although family and twin studies have shown genetic factors to play a key role in …

Abstract Objective Psoriatic arthritis (PsA) is a common inflammatory joint disease distinct
from other chronic arthritides and frequently accompanied by psoriasis vulgaris. In a first …

Background Genome-wide association studies (GWASs) have revealed a large number of
genetic risk loci for many autoimmune diseases. One clear finding emerging from the …

To identify susceptibility genes for amyotrophic lateral sclerosis (ALS), we conducted a
genome-wide association study (GWAS) in 506 individuals with sporadic ALS and 1,859 …

Association studies among admixed populations pose many challenges including
confounding of genetic effects due to population substructure and heterogeneity due to …