Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

M Xin, EN Olson, R Bassel-Duby - Nature reviews Molecular cell …, 2013 - nature.com
As the adult mammalian heart has limited potential for regeneration and repair, the loss of
cardiomyocytes during injury and disease can result in heart failure and death. The cellular …

Molecular and genetic basis of sudden cardiac death

AL George - The Journal of clinical investigation, 2013 - Am Soc Clin Investig
The abrupt cessation of effective cardiac function due to an aberrant heart rhythm can cause
sudden and unexpected death at any age, a syndrome called sudden cardiac death (SCD) …

CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia

E Di Pasquale, F Lodola, M Miragoli, M Denegri… - Cell death & …, 2013 - nature.com
Induced pluripotent stem cells (iPSC) offer a unique opportunity for developmental studies,
disease modeling and regenerative medicine approaches in humans. The aim of our study …

New and TALENted genome engineering toolbox

JM Campbell, KA Hartjes, TJ Nelson, X Xu… - Circulation …, 2013 - Am Heart Assoc
Recent advances in the burgeoning field of genome engineering are accelerating the
realization of personalized therapeutics for cardiovascular disease. In the postgenomic era …

Modeling anesthetic developmental neurotoxicity using human stem cells

X Bai, D Twaroski, ZJ Bosnjak - Seminars in cardiothoracic …, 2013 - journals.sagepub.com
Mounting preclinical evidence in rodents and nonhuman primates has demonstrated that
prolonged exposure of developing animals to general anesthetics can induce widespread …

Cardiovascular science: opportunities for translating research into improved care

E Braunwald - The Journal of clinical investigation, 2013 - Am Soc Clin Investig
Cardiovascular research is progressing on many fronts, as highlighted in the collection of
Reviews in this issue of the JCI. MicroRNAs that regulate cardiac function have been …

[HTML][HTML] Emerging model in anesthetic developmental neurotoxicity: human stem cells

X Bai, ZJ Bosnjak - International journal of clinical anesthesiology, 2013 - ncbi.nlm.nih.gov
It is well known that the prolonged exposure of developing animals such as rodents and
nonhuman primates to general anesthetics can induce widespread neuronal cell death …

Development of a T cell based cancer immunotherapy by using the induced pluripotent stem cell

F Lei - 2013 - etda.libraries.psu.edu
Cancer is one of the leading health issues that has caused tremendous impacts.
Conquering cancer is imminent and finding more potent treatments to cancer is also urgent …

[PDF][PDF] ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СТВОЛОВЫХ КЛЕТОК У БОЛЬНЫХ ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА (ОБЗОР ЛИТЕРАТУРЫ)

ПТ Мачавариани, ХА Джалабадзе… - GEORGIAN …, 2013 - researchgate.net
Несмотря на то, что, наряду с интенсивной медикаментозной терапией, при лечении
некоторых видов ИБС–стенокардии и острого инфаркта миокарда (ОИМ), применяют …