Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier

M Hawkes, RE Elphinstone, AL Conroy, KC Kain - Virulence, 2013 - Taylor & Francis
Malaria affects millions of people around the world and a small subset of those infected
develop cerebral malaria. The clinical presentation of cerebral malaria differs between …

Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria

NO Wilson, W Solomon, L Anderson, J Patrickson… - PloS one, 2013 - journals.plos.org
Despite appropriate anti-malarial treatment, cerebral malaria (CM)-associated mortalities
remain as high as 30%. Thus, adjunctive therapies are urgently needed to prevent or reduce …

Immunobiology of Plasmodium in liver and brain

U Frevert, A Nacer - Parasite Immunology, 2013 - Wiley Online Library
Malaria remains one of the most serious health problems globally, but our understanding of
the biology of the parasite and the pathogenesis of severe disease is still limited. Multiple …

Experimental cerebral malaria is suppressed by disruption of nucleoside transporter 1 but not purine nucleoside phosphorylase

M Niikura, SI Inoue, S Mineo, Y Yamada… - Biochemical and …, 2013 - Elsevier
Protozoan parasites rely on purine nucleosides supplied by the host because they are
unable to synthesise purine rings denovo. Nucleoside transporter 1 (NT1) and purine …

Experimental cerebral malaria develops independently of endothelial expression of intercellular adhesion molecule-1 (icam-1)

TN Ramos, DC Bullard, MM Darley, K McDonald… - Journal of Biological …, 2013 - ASBMB
Cerebral malaria (CM) is a severe clinical complication of Plasmodium falciparum malaria
infection and is characterized by a high fatality rate and neurological damage. Sequestration …

Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of …

B DellaValle, T Staalsoe, JAL Kurtzhals, C Hempel - PLoS One, 2013 - journals.plos.org
Introduction Cerebral malaria (CM) is a potentially fatal cerebrovascular disease of complex
pathogenesis caused by Plasmodium falciparum. Hydrogen sulfide (HS) is a physiological …

Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood–brain …

HL Johnson, LM Hanson, Y Chen, AJ Bieber… - BMC genomics, 2013 - Springer
Background Blood–brain barrier (BBB) disruption is an integral feature of numerous
neurological disorders. However, there is a relative lack of knowledge regarding the …

[PDF][PDF] Facultad de Estudios Superiores Zaragoza

CJ ANGÓN - 2013 - zaragoza.unam.mx
Este trabajo de tesis tiene como objetivo realizar el análisis de la medición de espesores de
una planta hidrodesulfuradora de diésel ultra bajo azufre, a partir de la información …

Inmunidad a la malaria letal en modelos murinos: adquisición espontánea o mediada por tratamiento quimioterapéutico.

I González Azcárate - 2013 - docta.ucm.es
Malaria is one of the most important global health problems and, together with tuberculosis
and HIV/AIDS, is one of the three infectious diseases that has the highest impact worldwide …

An investigation into the pre-erythrocytic immune responses that modulate Plasmodium berghei immunopathology and protect against experimental cererbal malaria

M Lewis - 2013 - archiv.ub.uni-heidelberg.de
Cerebral malaria is caused by a complicated series of immune reactions in the host, marked
by inflammatory immune responses, margination of leukocytes and parasitized erythrocytes …