CXCR4 is a G-protein-coupled receptor involved in a number of physiological processes in
the hematopoietic and immune systems. The SDF-1/CXCR4 axis is significantly associated …

Chloroquine and hydroxychloroquine are still used for the prevention and treatment of
malaria. Moreover, they are experiencing a renaissance in the long-term therapy of …

Rationale: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation
and apoptosis resistance in pulmonary artery smooth muscle cells (PASMCs). Objective: We …

OBJECTIVES: Hydroxychloroquine is an antimalarial agent that has been used in systemic
lupus erythematosus and rheumatoid arthritis treatment for many years. Recently, novel …

For more than two decades, chloroquine (CQ) was largely and deliberately used as first
choice drug for malaria treatment. However, worldwide increasing cases of resistant strains …

The ability of neutrophils and other leucocyte members of the innate immune system to
expel their DNA into the extracellular environment in a controlled manner in order to trap …

Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif
act as antagonists of Toll-like receptor (TLR) 7 and TLR9. In the present study, we designed …

Pulmonary arterial hypertension (PAH) is characterized by dysregulated pulmonary artery
endothelial cell (PAEC) proliferation, apoptosis and permeability. Loss-of-function mutations …

The work aimed at studying a novel topical niosomal gel formulation of hydroxychloroquine
for the management of oral lichen planus. Niosomes have been reported as conceivable …

Despite the major advances in the management of HIV infection, HIV-infected patients still
have greater morbidity and mortality than the general population. Serious non-AIDS events …