Shank/ProSAP proteins are major scaffold proteins of the postsynaptic density; mutations in
the human SHANK3 gene are associated with intellectual disability or autism spectrum …

Social isolation in adulthood is a psychosocial stressor that can result in endocrinological
and behavioral alterations in different species. In rodents, controversial results have been …

Polysialic acid (PSA) is a homopolymeric glycan that plays crucial roles in the developing
and adult nervous system. So far only a few PSA-binding proteins have been identified …

Cytoplasmic dynein is well characterized as an organelle motor, but dynein also acts to
tether and stabilize dynamic microtubule plus-ends in vitro. Here we identify a novel and …

Synapse elimination and pruning of axon collaterals are crucial developmental events in the
refinement of neuronal circuits. While a control of synapse formation by adhesion molecules …

BACKGROUND: Normal brain maturation is the result of molecular changes that can be
modulated by endocrine variables associated with brain plasticity and results in sex-and age …

The molecular cascade of events associated with hippocampal processing of information for
long-term storage is a time-limited event. Learning sets in motion neural processes that …

The neuromuscular junction (NMJ) is a synapse formed between a motoneuron and a
muscle fiber which transmits the signals required to initiate muscle contraction. The …

A família de proteínas Shank é o principal conjunto de proteinas de suporte e está
localizada na densidade pós-sináptica das sinapses excitatórias. Existem 3 genes na …

Sialic acids are family of nine carbon α-keto acids found to have important roles mammals
and bacteria. They are negatively charged sugars which have found to play critical roles in …