Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far?
In light of the number of studies conducted to examine the treatment of cognitive impairment
associated with schizophrenia (CIAS), we critically reviewed recent CIAS trials. Trials were …
associated with schizophrenia (CIAS), we critically reviewed recent CIAS trials. Trials were …
[HTML][HTML] Pharmacogenetics of antidepressants, mood stabilizers, and antipsychotics in diverse human populations
E Murphy, FJ McMahon - Discovery medicine, 2013 - ncbi.nlm.nih.gov
An increasing focus on personalized medicine is driving a renewed effort to understand the
impact of ethnic and genetic background on treatment outcomes. Since responses to …
impact of ethnic and genetic background on treatment outcomes. Since responses to …
Inflammatory and immune response genes have significantly altered expression in schizophrenia
J Sainz, I Mata, J Barrera, R Perez-Iglesias… - Molecular …, 2013 - nature.com
1 Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J et al. De novo gene
disruptions in children on the autistic spectrum. Neuron 2012; 74: 285–299. 2 Neale BM …
disruptions in children on the autistic spectrum. Neuron 2012; 74: 285–299. 2 Neale BM …
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment
Objective To examine the unique and congruent findings between multiple raters in a
genome-wide association study (GWAS) in the context of understanding individual …
genome-wide association study (GWAS) in the context of understanding individual …
Association study of neuregulin-1 gene polymorphisms in a North Indian schizophrenia sample
BACKGROUND: Neuregulin-1 (NRG1) gene polymorphisms have been proposed as risk
factors for several common disorders. Associations with cognitive variation have also been …
factors for several common disorders. Associations with cognitive variation have also been …
Schizophrenia: Evolution and synthesis
Leading researchers address conceptual and technical issues in schizophrenia and suggest
novel strategies for advancing research and treatment. Despite major advances in …
novel strategies for advancing research and treatment. Despite major advances in …
Genotype-based ancestral background consistently predicts efficacy and side effects across treatments in CATIE and STAR* D
Only a subset of patients will typically respond to any given prescribed drug. The time it
takes clinicians to declare a treatment ineffective leaves the patient in an impaired state and …
takes clinicians to declare a treatment ineffective leaves the patient in an impaired state and …
Investigation of genetic variation contributing to antipsychotic treatment response in a South African first episode schizophrenia cohort
BI Drogemoller - 2013 - scholar.sun.ac.za
Schizophrenia is a debilitating disorder that occurs the world over. Although antipsychotics
are largely effective in treating the positive symptoms of schizophrenia, the outcomes are …
are largely effective in treating the positive symptoms of schizophrenia, the outcomes are …
Vera A. Morgan, Richard Keefe, René S. Kahn, Anil K. Malhotra, Andreas Meyer-Lindenberg, Kim T. Mueser, Karoly Nikolich, Wulf Rössler, William Spaulding …
W Spaulding - Evolution and Synthesis, 2013 - books.google.com
This chapter is framed by four perspectives. The first views schizophrenia as a
heterogeneous disorder that may present itself very differently across individuals …
heterogeneous disorder that may present itself very differently across individuals …
[PDF][PDF] Genome-wide association study of patient and clinician rated global impression severity during antipsychotic treatment
SL Clarka, RP Souzab, DE Adkinsa… - Pharmacogenet …, 2013 - academia.edu
Objective—Examine the unique and congruent findings between multiple raters in a
genomewide association studies (GWAS) in the context of understanding individual …
genomewide association studies (GWAS) in the context of understanding individual …