Changes in DNA copy number, whether confined to specific genes or affecting whole
chromosomes, have been identified as causes of diseases and developmental …

Aging is the main risk factor for most chronic diseases, disabilities, and declining health. It
has been proposed that senescent cells—damaged cells that have lost the ability to divide …

The BubR1 gene encodes for a mitotic regulator that ensures accurate segregation of
chromosomes through its role in the mitotic checkpoint and the establishment of proper …

Aneuploidy, a chromosome content other than a multiple of the haploid number, is a
common feature of cancer cells. Whole chromosomal aneuploidy accompanying ongoing …

The eukaryotic cell cycle is conventionally viewed as comprising several discrete steps,
each of which must be completed before the next one is initiated. However, emerging …

Oxidative stress is a determining factor of cellular senescence and aging and a potent
inducer of the tumour‐suppressor p53. Resistance to oxidative stress correlates with …

Sarcopenia, defined as muscle weakness and fiber atrophy, of respiratory muscles such as
the diaphragm (DIAm) has not been well characterized. The DIAm is the main inspiratory …

BubR1 insufficiency occurs with natural aging and induces progeroid phenotypes in both
mice and children with mosaic variegated aneuploidy syndrome. In response to BubR1 …

Aneuploidy, an aberrant number of chromosomes, has been recognized as a feature of
human malignancies for over a century, but compelling evidence for causality was largely …

The spindle assembly checkpoint is a conserved signalling pathway that protects genome
integrity. Given its central importance, this checkpoint should withstand stochastic …