Brown adipose tissue (BAT) is a major site of nonshivering thermogenesis in mammals.
Rodent studies indicated that BAT thermogenic activity may protect against obesity. Recent …

Nuclear receptors are ligand-activated transcription factors and include the receptors for
steroid hormones, lipophilic vitamins, sterols, and bile acids. These receptors serve as …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

Context: Recently irisin (encoded by Fndc5 gene) has been reported to stimulate browning
and uncoupling protein 1 expression in sc adipose tissue of mice. Objective: The objective of …

The master transcription factor Pparγ regulates the general differentiation program of both
brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat …

Adipose tissue is an important metabolic organ, the dysfunction of which is associated with
the development of obesity, diabetes mellitus, and cardiovascular disease. The nuclear …

When humans eat more and exercise less, they tend to become obese and unhealthy. The
molecular pathways that link obesity to serious diseases like Type 2 diabetes and …

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and play a
critical role in skeletal development, bone formation and stem cell differentiation. Disruptions …

Transcriptional effectors of white adipocyte-selective gene expression have not been
described. Here we show that TLE3 is a white-selective cofactor that acts reciprocally with …

The zinc-finger transcription factors of the kruppel-like factor family (KLF) are critical in many
physiological and pathological processes including cell proliferation, differentiation …