Over several decades, various forms of genomic analysis of the human major
histocompatibility complex (MHC) have been extremely successful in picking up many …

Highlights•Narcolepsy is caused by the loss of hypocretin-producing neurons in the
brain.•HLA DQB1* 06: 02 association suggests an autoimmune basis for narcolepsy.• …

DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility
to a wide range of human diseases. The complex genetic structure of the major …

Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not
specific, predictors of metastatic disease and lethal prostate cancer. We hypothesize that a …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

Allopurinol is the most commonly used drug for the treatment of hyperuricemia and gout.
However, allopurinol is also one of the most common causes of severe cutaneous adverse …

Genetic variation in a population can be summarized through principal component analysis
(PCA) on genome-wide data. PCs derived from such analyses are valuable for genetic …

Genetic studies in immune-mediated diseases have yielded a large number of disease-
associated loci. Here we review the progress being made in 12 such diseases, for which …

Allergic diseases are complex diseases caused by a combination of genetic and
environmental factors. To determine the genetic components of these diseases and to …

Interactions between HLA class I molecules and killer-cell immunoglobulin-like receptors
(KIR) control natural killer cell (NK) functions in immunity and reproduction. Encoded by …