Exosomes are small membrane vesicles of endocytic origin with a size of 50–100 nm. They
can contain microRNAs, mRNAs, DNA fragments, and proteins, which are shuttled from a …

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human
epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene …

Glioblastoma (GBM) is the most common and lethal primary brain tumor. Over the past few
years tremendous genomic and proteomic characterization along with robust animal models …

Glioblastomas are heterogeneous neoplasms that are driven by complex signalling
pathways, and are among the most aggressive and challenging cancers to treat. Despite …

EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein
product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes …

Epidermal growth factor receptor (EGFR) gene mutations and increased EGFR copy
numbers have been associated with a favorable response to EGFR tyrosine kinase …

In multicellular organisms both health and disease are defined by patterns of communication
between the constituent cells. In addition to networks of soluble mediators, cells are also …

BACKGROUND AND PURPOSE: Tumor location is a significant prognostic factor in
glioblastoma, which may reflect the genetic profile of tumor precursor cells. The purpose of …

Malignant gliomas are one of the most treatment-refractory cancers. Development of
resistance to chemo-and radio-therapies contributes to these tumors 'aggressive …

Tumor cells activate pathways that facilitate and stimulate glycolysis even in the presence of
adequate levels of oxygen in order to satisfy their continuous need of molecules, such as …