Mutations in nuclear lamins or other proteins of the nuclear envelope are the root cause of a
group of phenotypically diverse genetic disorders known as laminopathies, which have …

The A‐and B‐type lamins are nuclear intermediate filament proteins in eukaryotic cells with
a broad range of functions, including the organization of nuclear architecture and interaction …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare segmental premature aging
disorder that recapitulates some biological and physical aspects of physiological aging. The …

Objective—Some mutations in LMNA, encoding A-type lamins, are responsible for Dunnigan-
type-familial partial lipodystrophy (FPLD2), with altered fat distribution and metabolism. The …

Arterial ageing is characterized by age associated degeneration and sclerosis of the media
layer of the large arteries. However, besides ageing, clinical conditions, which enhance …

Lamin A and the B-type lamins, lamin B1 and lamin B2, are translated as pre-proteins that
are modified at a carboxyl terminal CAAX motif by farnesylation, proteolysis and …

A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of
Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss …

Transgenic animals are extensively used to model human disease. Typically, the transgene
copy number is estimated, but the exact integration site and configuration of the foreign DNA …

Herein, we describe our development of synthetic methods for heterocyclic compounds
based on the palladium-catalyzed carbon–hydrogen bond (C–H) functionalization …

We present here the NHC‐dirhodium (II)/DBU‐catalyzed ring expansion reaction of isatins
with ethyl diazoacetate. This new one‐pot protocol yields the ethyl 3‐hydroxy‐2 (1H) …