Pancreastatin (PST) is a regulatory peptide containing 49 amino acids, first isolated from
porcine pancreas. Intracellular and extracellular processing of the prohormone …

The regulated secretory pathway provides critical control of peptide, growth factor, and
hormone release from neuroendocrine and endocrine cells, and neurons, maintaining …

Psychiatric disorders are caused by perturbed molecular pathways that affect brain
circuitries. The identification of specific biosignatures that are the result of altered pathway …

Mass spectrometry-based unbiased analysis of the full complement of secretory peptides is
expected to facilitate the identification of unknown biologically active peptides. However …

Argonaute2 (Ago2) is an established component of the microRNA-induced silencing
complex. Similar to miR-375 loss-of-function studies, inhibition of Ago2 in the pancreatic β …

The secretory sorting receptors carboxypeptidase E (CPE) and secretogranin III (SgIII)
critically activate peptidic messengers and targeting them at the regulated secretory …

Peptide Hormone Acquisition through Smart Sampling Technique-Mass Spectrometry
(PHASST-MS) is a peptidomics platform that employs high resolution liquid chromatography …

The chronic use of nicotine, the main psychoactive ingredient of tobacco smoking, alters
diverse physiological processes and consequently generates physical dependence. To …

Background: VGF (non-acronymic), a protein expressed in the hypothalamus and pituitary, is
involved in the control of metabolism and body weight homeostasis. Different active peptide …

Chromogranins (Cgs) are acidic proteins implicated in several physiological processes,
including the biogenesis and sorting of secretory vesicles, the generation of bioactive …