The naphthoquinone shikonin is the main active principle of Zicao, a traditional Chinese
herbal medicine made from the dried root of Lithospermum erythrorhizon. Studies carried …

Quinones are plant-derived secondary metabolites that present some anti-proliferation and
anti-metastasis effects in various cancer types both in vitro and in vivo. This review focuses …

Shikonin is the major constituent of the root of Lithospermum erythrorhizon, which has been
used in traditional Chinese medicine to treat external wounds, burns, or dermatitis for …

Although various pharmacological activities of the shikonins have been documented,
understanding the hierarchical regulation of these diverse bioactivities at the genome level …

Background The naphthoquinone pigment, shikonin, is a major component of Lithospermum
erythrorhizon and has been shown to have various biological functions, including …

Integrin β1 facilitates cancer cell adhesion, migration and metastasis by activating
intracellular signaling pathways including the ERK and PI3K signaling pathways. In previous …

Shikonin (SHK), a natural naphthoquinone derived from the Chinese medical herb
Lithospermum erythrorhizon, induces both apoptosis and necroptosis in several cancer cell …

BACKGROUND: Shikonin, a natural naphthoquinone pigment extracted from the root of
Lithospermum erythrorhizon, has shown a variety of pharmacologic properties including anti …

ETHNOPHARMACOLOGICAL RELEVANCE: Shikonin, a highly liposoluble naphthoquinone
pigment isolated from the traditional medical herbs Lithospermum erythrorhizon (LE), was …

To search for compounds that disrupt binding of the EWS-FLI1 fusion protein to its cognate
targets, we developed a homogeneous high-throughput proximity assay and screened 5200 …