Aging is the largest risk factor for most chronic diseases, which account for the majority of
morbidity and health care expenditures in developed nations. New findings suggest that …

For most species, aging promotes a host of degenerative pathologies that are characterized
by debilitating losses of tissue or cellular function. However, especially among vertebrates …

Monitoring cancer and aging in vivo remains experimentally challenging. Here, we describe
a luciferase knockin mouse (p16 LUC), which faithfully reports expression of p16 INK4a, a …

Autophagy and apoptosis are crucial cellular housekeeping and tissue survival
mechanisms. There is emerging evidence of important crosstalk between apoptosis and …

Cellular senescence is a stable proliferation arrest associated with an altered secretory
pathway (senescence-associated secretory phenotype). Cellular senescence is also a tumor …

Here we present and develop the hypothesis that the derepression of endogenous
retrotransposable elements (RTEs)–“genomic parasites”–is an important and hitherto under …

The squamous epithelium covering the skin and oral mucosa relies on epithelial stem cells
for tissue renewal. Dynamic changes in DNA methylation, histone methylation and …

Serial passaging has a profound effect on primary cells. Since serially passaged cells show
signs of cellular aging, serial passaging is used as an in vitro model of aging. To relate the …

Methylation of DNA is intimately involved in control of mammalian/vertebrate gene
expression as part of a complex epigenetic regulatory system. We hypothesize that DNA …

Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs
following either a replicative or an oncogenic stimulus. This phenomenon occurs as a …