Curcumin (diferuloylmethane), a polyphenol extracted from the plant Curcuma longa, is
widely used in Southeast Asia, China and India in food preparation and for medicinal …

The Notch signaling pathway is evolutionarily conserved and responsible for cell fate
determination in the developing embryo and mature tissue. At the molecular level, ligand …

Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder believed to
be initiated by accumulation of amyloid β (Aβ)-related peptides derived from proteolytic …

Presenilins (PSs) are the catalytic core of γ-secretase complex. However, the mechanism of
FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the …

With roughly 234 million people undergoing surgery with anesthesia each year worldwide, it
is important to determine whether commonly used anesthetics can induce any neurotoxicity …

Understanding the substrate recognition mechanism of γ-secretase is a key step for
establishing substrate-specific inhibition of amyloid β-protein (Aβ) production. However, it is …

Presenilin is the catalytic component of the γ-secretase complex, a membrane-embedded
aspartyl protease that plays a central role in biology and in the pathogenesis of Alzheimer's …

Endosomal sorting of the Alzheimer amyloid precursor protein (APP) plays a key role in the
biogenesis of the amyloid-β (Aβ) peptide. Genetic lesions underlying Alzheimer's disease …

Presenilin and signal peptide peptidase are multispanning intramembrane-cleaving
proteases with a conserved catalytic GxGD motif. Presenilin comprises the catalytic subunit …

Alzheimer's disease (AD) is characterized by progressive memory loss accompanied by
synaptic and neuronal degeneration. Although research has shown that substantial …