Two major mechanisms are involved in the formation of blood vasculature: vasculogenesis
and angiogenesis. The former term describes the formation of a capillary-like network from …

The flow of interstitial fluid and the associated interstitial fluid pressure (IFP) in solid tumors
and surrounding host tissues have been identified as critical elements in cancer growth and …

Colon rectal cancers (CRC) are the result of sequences of mutations which lead the
intestinal tissue to develop in a carcinoma following a “progression” of observable …

In this paper we present a continuum mathematical model of vascular tumour growth which
is based on a multiphase framework in which the tissue is decomposed into four distinct …

The paper addresses modeling of avascular and vascular tumor growth within the
framework of continuum mechanics and the adopted numerical solution strategies. The …

This work presents a continuous model for three early stage events in angiogenesis:
initiation, sprout extension, and vessel maturation. We carefully examine the regulating …

Background Recently, melanoma has become the most malignant and commonly occurring
skin cancer. Melanoma is not only the major source (75%) of deaths related to skin cancer …

Changes in extracellular matrix (ECM) structure or mechanics can actively drive cancer
progression; however, the underlying mechanism remains unknown. Here we explore …

The present work formulates and analyzes the inhibitory effect of anti-angiogenic factor
angiostatin excreted by the primary tumor on metastatic tumor angiogenesis, blood …

Antiangiogenic drugs were developed with the aim to inhibit the formation of intratumoral
blood vessels and in consequence the growth of solid tumors. As these drugs are generally …