Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice
YP Deng, T Wong, C Bricker-Anthony, B Deng… - Neurobiology of …, 2013 - Elsevier
Motor slowing, forebrain white matter loss, and striatal shrinkage have been reported in
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …
premanifest Huntington's disease (HD) prior to overt striatal neuron loss. We carried out …
Antisense oligonucleotide-mediated correction of transcriptional dysregulation is correlated with behavioral benefits in the YAC128 mouse model of Huntington's …
Background: Huntington's disease (HD) is a neurological disorder caused by mutations in
the huntingtin (HTT) gene, the product of which leads to selective and progressive neuronal …
the huntingtin (HTT) gene, the product of which leads to selective and progressive neuronal …
Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease
P Samadi, A Boutet, VV Rymar, K Rawal… - Genes, Brain and …, 2013 - Wiley Online Library
Patients with Huntington's disease (HD) and transgenic mouse models of HD show neuronal
loss in the striatum as a major feature, which contributes to cognitive and motor …
loss in the striatum as a major feature, which contributes to cognitive and motor …
Transplantation of GABAergic cells derived from bioreactor-expanded human neural precursor cells restores motor and cognitive behavioral deficits in a rodent model …
MC McLeod, NR Kobayashi, A Sen… - Cell …, 2013 - journals.sagepub.com
Huntington's disease (HD) is a neurodegenerative disorder that is characterized by
progressive dementia, choreiform involuntary movements, and emotional deterioration …
progressive dementia, choreiform involuntary movements, and emotional deterioration …
Investigating the role of Indoleamine 2, 3 dioxygenase in Huntington disease
G Mazarei - 2013 - open.library.ubc.ca
The striatum is predominantly affected in Huntington disease (HD). To address this selective
degeneration, we previously studied the gene expression profile in mouse brain and …
degeneration, we previously studied the gene expression profile in mouse brain and …
Basal Ganglia Disorders
AB West, M Gray, DG Standaert - Emery and Rimoin's Essential …, 2013 - books.google.com
Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics,
University of Alabama at Birmingham, AL, USA for disease. Additional genetic factors …
University of Alabama at Birmingham, AL, USA for disease. Additional genetic factors …