Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity
I Gomes, W Fujita, A Gupta… - Proceedings of the …, 2013 - National Acad Sciences
G protein-coupled receptors play a pivotal role in many physiological signaling pathways.
Mounting evidence suggests that G protein-coupled receptors, including opioid receptors …
Mounting evidence suggests that G protein-coupled receptors, including opioid receptors …
Inferring multi-target QSAR models with taxonomy-based multi-task learning
Background A plethora of studies indicate that the development of multi-target drugs is
beneficial for complex diseases like cancer. Accurate QSAR models for each of the desired …
beneficial for complex diseases like cancer. Accurate QSAR models for each of the desired …
Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data …
S Paricharak, T Klenka, M Augustin, UA Patel… - Journal of …, 2013 - Springer
Background 'Phylogenetic trees' are commonly used for the analysis of chemogenomics
datasets and to relate protein targets to each other, based on the (shared) bioactivities of …
datasets and to relate protein targets to each other, based on the (shared) bioactivities of …
[PDF][PDF] Ivone Gomesa, Wakako Fujitaa, Achla Guptaa, S. Adrian Saldanhab, Ana Negric, Christine E. Pinellob, Christina Eberhartb, Edward Robertsd, Marta Filizolac …
S Volkensteina, K Oshimaa, ST Sinkkonena… - PNAS, 2013 - researchgate.net
Correction for “Transient, afferent input-dependent, postnatal niche for neural progenitor
cells in the cochlear nucleus,” by Stefan Volkenstein, Kazuo Oshima, Saku T. Sinkkonen, C …
cells in the cochlear nucleus,” by Stefan Volkenstein, Kazuo Oshima, Saku T. Sinkkonen, C …
Improving drug discovery using a neural networks based parallel scoring function
H Pérez-Sánchez, GD Guerrero… - … Joint Conference on …, 2013 - ieeexplore.ieee.org
Virtual Screening (VS) methods can considerably aid clinical research, predicting how
ligands interact with drug targets. Most VS methods suppose a unique binding site for the …
ligands interact with drug targets. Most VS methods suppose a unique binding site for the …
Computational approaches to predicting drug induced toxicity
RL Marchese Robinson - 2013 - repository.cam.ac.uk
Novel approaches and models for predicting drug induced toxicity in silico are presented.
Typically, these were based on Quantitative Structure-Activity Relationships (QSAR). The …
Typically, these were based on Quantitative Structure-Activity Relationships (QSAR). The …
[引用][C] CATS for Scaffold Hopping in Medicinal Chemistry
CP Koch, M Reutlinger, N Todoroff… - Scaffold Hopping in …, 2013 - Wiley Online Library
CATS for Scaffold Hopping in Medicinal Chemistry Page 1 7 CATS for Scaffold Hopping in
Medicinal Chemistry Christian P. Koch, Michael Reutlinger, Nickolay Todoroff, Petra Schneider …
Medicinal Chemistry Christian P. Koch, Michael Reutlinger, Nickolay Todoroff, Petra Schneider …