Mechanisms of diabetic complications

JM Forbes, ME Cooper - Physiological reviews, 2013 - journals.physiology.org
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Effects of exenatide and liraglutide on heart rate, blood pressure and body weight: systematic review and meta-analysis

LE Robinson, TA Holt, K Rees, HS Randeva… - BMJ open, 2013 - bmjopen.bmj.com
Objectives To synthesise current evidence for the effects of exenatide and liraglutide on
heart rate, blood pressure and body weight. Design Meta-analysis of available data from …

Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study

JB Buse, M Nauck, T Forst, WHH Sheu, SK Shenouda… - The Lancet, 2013 - thelancet.com
Background Glucagon-like peptide-1 receptor agonists exenatide and liraglutide have been
shown to improve glycaemic control and reduce bodyweight in patients with type 2 diabetes …

[HTML][HTML] Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes

RA DeFronzo, R Eldor, M Abdul-Ghani - Diabetes care, 2013 - ncbi.nlm.nih.gov
Two general approaches to the treatment of type 2 diabetes mellitus (T2DM) have been
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …

A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe?

PC Butler, M Elashoff, R Elashoff, EAM Gale - Diabetes care, 2013 - Am Diabetes Assoc
There is no question that incretin-based glucose-lowering medications have proven to be
effective glucose-lowering agents. Glucagon-like peptide 1 (GLP-1) receptor agonists …

Efficacy and safety of lixisenatide once daily versus exenatide twice daily in type 2 diabetes inadequately controlled on metformin: a 24-week, randomized, open-label …

J Rosenstock, D Raccah, L KORanyi, L Maffei… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE To compare efficacy and safety of lixisenatide once daily versus exenatide
twice daily in type 2 diabetes inadequately controlled with metformin. RESEARCH DESIGN …

Blood pressure‐lowering effects of GLP‐1 receptor agonists exenatide and liraglutide: a meta‐analysis of clinical trials

B Wang, J Zhong, H Lin, Z Zhao, Z Yan… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aims Aside from lowering blood glucose, glucagon‐like peptide‐1 receptor agonists (GLP‐1
RAs) attract much attention because of their cardioprotective effects. The aim of this study …

[HTML][HTML] Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial

SP Marso, NR Poulter, SE Nissen, MA Nauck… - American heart …, 2013 - Elsevier
Background Diabetes is a multisystem disorder associated with a nearly twofold excess risk
for a broad range of adverse cardiovascular outcomes including coronary heart disease …

A critical analysis of the clinical use of incretin-based therapies: the benefits by far outweigh the potential risks

MA Nauck - Diabetes care, 2013 - Am Diabetes Assoc
There is no question that incretin-based glucose-lowering medications have proven to be
effective glucose-lowering agents. Glucagon-like peptide 1 (GLP-1) receptor agonists …

Long‐term efficacy and safety comparison of liraglutide, glimepiride and placebo, all in combination with metformin in type 2 diabetes: 2‐year results from the LEAD‐2 …

M Nauck, A Frid, K Hermansen… - Diabetes, Obesity …, 2013 - Wiley Online Library
Aims To investigate efficacy and safety of dual therapy with liraglutide and metformin in
comparison to glimepiride and metformin, and metformin monotherapy over 2 years in …