Pentraxins: structure, function, and role in inflammation

TW Du Clos - International Scholarly Research Notices, 2013 - Wiley Online Library
The pentraxins are an ancient family of proteins with a unique architecture found as far back
in evolution as the Horseshoe crab. In humans the two members of this family are C‐reactive …

Interpretation of C‐reactive protein concentrations in critically ill patients

C Lelubre, S Anselin… - BioMed research …, 2013 - Wiley Online Library
Infection is often difficult to recognize in critically ill patients because of the marked
coexisting inflammatory process. Lack of early recognition prevents timely resuscitation and …

Procalcitonin versus C-reactive protein for guiding antibiotic therapy in sepsis: a randomized trial

CF Oliveira, FA Botoni, CRA Oliveira… - Critical care …, 2013 - journals.lww.com
Objective: We sought to evaluate whether procalcitonin was superior to C-reactive protein in
guiding antibiotic therapy in intensive care patients with sepsis. Design: Randomized open …

Changes and regulation of the C5a receptor on neutrophils during septic shock in humans

H Unnewehr, D Rittirsch, JV Sarma… - The Journal of …, 2013 - journals.aai.org
During experimental sepsis, excessive generation of the anaphylatoxin C5a results in
reduction of the C5a receptor (C5aR) on neutrophils. These events have been shown to …

Diagnostic and prognostic markers in sepsis

JL Vincent, M Beumier - Expert review of anti-infective therapy, 2013 - Taylor & Francis
Sepsis is a common and serious complication in intensive care unit patients. An important
factor in optimizing survival rates in septic patients is the ability to start treatment early in the …

Clinical application of sepsis biomarkers

V Sankar, NR Webster - Journal of anesthesia, 2013 - Springer
Sepsis is one of the leading causes of death in the critically ill. Early diagnosis is important to
avoid delay in instituting appropriate treatment. However, diagnosis can be delayed …

C-reactive protein and later preeclampsia: systematic review and meta-analysis taking into account the weight status

F Rebelo, MM Schluessel, JS Vaz… - Journal of …, 2013 - journals.lww.com
Objectives: This study aims to determine whether high C-reactive protein (CRP)
concentration during pregnancy is associated with later preeclampsia and whether weight …

重症肺炎合并脓毒症患儿炎症因子及凝血指标与危重症评分相关性分析

杨秀霖, 王程毅, 郑启安, 张荣娜, 王世彪, 宋朝敏 - 中国循证儿科杂志, 2013 - cjebp.net
目的探讨重症肺炎合并脓毒症患儿炎症因子和凝血指标与危重症评分的相关性. 方法选择2010
年1 月至2012 年11 月在福建省妇幼保健院PICU 入住24 h 以上, 符合重症肺炎合并脓毒症诊断 …

High-sensitivity C-reactive protein and risk of sepsis

HE Wang, NI Shapiro, MM Safford, R Griffin, S Judd… - PloS one, 2013 - journals.plos.org
Background Conventional C-reactive protein assays have been used to detect or guide the
treatment of acute sepsis. The objective of this study was to determine the association …

Evaluation of the Mortality in Emergency Department Sepsis score combined with procalcitonin in septic patients

Y Zhao, C Li, Y Jia - The American journal of emergency medicine, 2013 - Elsevier
Objective To determine an effective method for predicting severity of sepsis and 28-day
mortality of emergency department (ED) patients, we compared the Mortality in Emergency …