Small molecules that modulate stem cell fate and function offer significant opportunities that
will allow the full realization of the therapeutic potential of stem cells. Rational design and …

BACKGROUND: The diversity of cell types and tissue types that originate throughout
development derives from the differentiation potential of embryonic stem cells and somatic …

Human embryonic stem cells (hESCs) are derived from the inner cell mass of the blastocyst.
Despite sharing the common property of pluripotency, hESCs are notably distinct from …

The defining features of embryonic stem cells (ESCs) are their self-renewing and pluripotent
capacities. Indeed, the ability to give rise into all cell types within the organism not only …

Postnatal and adult human and monkey fibroblasts were infected with Sendai virus
containing the Yamanaka factors for 24 hr, then they were cultured in a chemically defined …

BACKGROUND: Stem cells are mainly characterized by two properties: self-renewal and the
potency to differentiate into diverse cell types. These processes are regulated by different …

Pluripotent stem cells offer unprecedented potential not only for human medicine but also for
veterinary medicine, particularly in relation to the horse. Induced pluripotent stem cells …

The domestic pig is an important large animal model for preclinical testing of novel cell
therapies. Recently, we produced pluripotency reporter pigs in which the Oct4 promoter …

Embryonic stem cells (ESCs) can proliferate indefinitely in vitro and differentiate into cells of
all three germ layers. These unique properties make them exceptionally valuable for drug …

Transplantation therapies aimed at repairing neurodegenerative and neuropathological
conditions of the central nervous system (CNS) have utilized and tested a variety of cell …