99mTc-labeled small-molecule inhibitors of prostate-specific membrane antigen for molecular imaging of prostate cancer

SM Hillier, KP Maresca, G Lu, RD Merkin… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and
small-molecule radiopharmaceuticals targeting PSMA rapidly detect the location and extent …

Prostate-specific membrane antigen protein expression in tumor tissue and risk of lethal prostate cancer

JL Kasperzyk, SP Finn, R Flavin, M Fiorentino… - … , biomarkers & prevention, 2013 - AACR
Background: Overexpression of prostate-specific membrane antigen (PSMA) in tumor tissue
and serum has been linked to increased risk of biochemical recurrence in surgically treated …

Opposing roles of folate in prostate cancer

KJ Rycyna, DJ Bacich, DS O'Keefe - Urology, 2013 - Elsevier
The US diet has been fortified with folic acid to prevent neural tube defects since 1998. The
Physician Data Queries from the National Cancer Institute describe folate as protective …

PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer

B Xiang, DW Dong, NQ Shi, W Gao, ZZ Yang, Y Cui… - Biomaterials, 2013 - Elsevier
In the hormone-refractory stage of prostate cancer (PC), the expression of prostate-specific
antigen (PSA) and prostate-specific membrane antigen (PSMA) often remains highly active …

Application of aptamers for targeted therapeutics

P Ray, KD Viles, EE Soule, RS Woodruff - Archivum immunologiae et …, 2013 - Springer
Aptamers are short, single-stranded oligonucleotides that are isolated through a process
termed systematic evolution of ligands by exponential enrichment. With the advent of cell …

Prostate Specific Membrane Antigen-Based Therapeutics

ST Tagawa, JR Osborne, S Vallabhajosula… - Prostate Cancer: A …, 2013 - Springer
Prostate cancer is the most common non-cutaneous malignancy affecting men in the US,
leading to significant morbidity and mortality. While significant therapeutic advances have …

Targeting prostate cancer cells with PSMA inhibitor-guided gold nanoparticles

BB Kasten, T Liu, JR Nedrow-Byers, PD Benny… - Bioorganic & medicinal …, 2013 - Elsevier
Prostate-specific membrane antigen (PSMA) is a notable biomarker for diagnostic and
therapeutic applications in prostate cancer. Gold nanoparticles (AuNPs) provide an …

Prostate specific membrane antigen (PSMA): a novel modulator of p38 for proliferation, migration, and survival in prostate cancer cells

Y Zhang, Z Guo, T Du, J Chen, W Wang, K Xu… - The …, 2013 - Wiley Online Library
BACKGROUND Regulated activation of p38 is crucial for cell proliferation, survival, and
metabolism. Our previous studies had showed that prostate specific membrane antigen …

Prostate specific membrane antigen produces pro-angiogenic laminin peptides downstream of matrix metalloprotease-2

RE Conway, K Joiner, A Patterson, D Bourgeois… - Angiogenesis, 2013 - Springer
Prostate specific membrane antigen (PSMA) is a pro-angiogenic cell-surface protease that
we previously demonstrated regulates blood vessel formation in a laminin and integrin β 1 …

Screening and identification of significant genes related to tumor metastasis and PSMA in prostate cancer using microarray analysis

L Xu, Z Wang, XF Li, X He, LL Guan… - Oncology …, 2013 - spandidos-publications.com
Tumor metastasis is one of the causes for the high mortality rate of prostate cancer (PCa)
patients, yet the molecular mechanisms of PCa metastasis are not fully understood. In our …