Increased oxidative stress has been associated with the aging process. However, recent
studies have revealed that a low-level oxidative stress can even extend the lifespan of …

Sirtuins are NAD‐dependent protein deacetylases known to have protective effects against
age‐related diseases such as cancer, diabetes, cardiovascular and neurodegenerative …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Genome instability has long been implicated as the main causal factor in aging. Somatic
cells are continuously exposed to various sources of DNA damage, from reactive oxygen …

Mitochondria are responsible for generating adenosine triphosphate (ATP) and metabolic
intermediates for biosynthesis. These dual functions require the activity of the electron …

In budding yeast, a mother cell can produce a finite number of daughter cells before it stops
dividing and dies. Such entry into senescence is thought to result from a progressive decline …

Abstract Sirtuins (SIRT1-7) are a highly conserved family of NAD+-dependent enzymes that
control the activity of histone and nonhistone regulatory proteins. SIRT1 is purposed to …

Genomic instability is a conserved factor in lifespan reduction, although the molecular
mechanism is not known [1]. Studies in the yeast Saccharomyces cerevisiae over the past …

Mitosis is the process of one cell dividing into two daughters, such that each inherits a single
and complete copy of the genome of their mother. This is achieved through the equal …

Aging and longevity are complex traits influenced by genetic and environmental factors. To
identify quantitative trait loci (QTLs) that control replicative lifespan, we employed an outbred …