Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of
stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase …

Polycomb group (PcG) proteins are epigenetic repressors that are essential for the
transcriptional control of cell differentiation and development. PcG-mediated repression is …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

Methylated lysine and arginine residues in histones represent a crucial part of the histone
code, and recognition of these methylated residues by protein interaction domains …

Polycomb protein histone methyltransferase, enhancer of Zeste homolog 2 (EZH2), is
frequently overexpressed in human malignancy and is implicated in cancer cell proliferation …

The importance of epigenetic gene regulatory mechanisms in normal and cancer
development is increasingly evident. Genome-wide analyses have revealed the mutation …

GATA-4 is an important transcription factor involved in several developmental processes of
the heart, such as cardiac myocyte proliferation, differentiation and survival. The precise …

Activated STAT3 and increased expression of the histone methyltransferase EZH2 are
independently associated with the most malignant subset of gliomas. In this issue of Cancer …