Seronegative antiphospholipid syndrome

R Nayfe, I Uthman, J Aoun, E Saad Aldin… - …, 2013 - academic.oup.com
APS is an autoimmune disease that leads to arterial and/or venous thrombosis, recurrent
pregnancy loss and persistently positive aPLs. Patients with clinical manifestations highly …

Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome

J Kwak‐Kim, MSL Agcaoili, L Aleta… - American Journal of …, 2013 - Wiley Online Library
Antiphospholipid antibodies (aPL) have been associated with recurrent pregnancy losses
(RPL) and other obstetrical complications. The diagnostic criteria for the classical …

Correct laboratory approach to APS diagnosis and monitoring

V Pengo, A Banzato, G Denas, SP Jose, E Bison… - Autoimmunity …, 2013 - Elsevier
Triple positivity (positive Lupus Anticoagulant, anticardiolipin and anti β2-glycoptrotein I
antibodies) identifies the pathogenic autoantibody (anti Domain I of β2-glycoptroteinI) that is …

Obstetrical antiphospholipid syndrome: from the pathogenesis to the clinical and therapeutic implications

T Marchetti, M Cohen… - Journal of Immunology …, 2013 - Wiley Online Library
Antiphospholipid syndrome (APS) is an acquired thrombophilia with clinical manifestations
associated with the presence of antiphospholipid antibodies (aPL) in patient plasma …

Evidence on the pathogenic role of auto-antibodies in acute cardiovascular diseases

F Carbone, A Nencioni, F Mach… - Thrombosis and …, 2013 - thieme-connect.com
Atherothrombosis is the major determinant of acute ischaemic cardiovascular events, such
as myocardial infarction and stroke. Inflammatory processes have been linked to all phases …

[PDF][PDF] The role of lupus anticoagulant and triple marker positivity as risk factors for rethrombosis in patients with primary antiphospholipid syndrome

G Hernández-Molina, G Espericueta-Arriola… - Clin Exp …, 2013 - clinexprheumatol.org
Methods We retrospectively evaluated 95 patients according to their rethrombotic status. We
registered anticoagulation (OA) status, comorbidities, traditional thrombotic factors …

Variability in exposure of epitope G40-R43 of domain i in commercial anti-beta2-glycoprotein I IgG ELISAs

L Pelkmans, H Kelchtermans, PG de Groot, S Zuily… - PloS one, 2013 - journals.plos.org
Background A major problem for diagnosing the antiphospholipid syndrome (APS) is the
high variability between commercial anti-β2glycoprotein I (β2GPI) assays. Predominantly …

Utility of antiphosphatidylserine/prothrombin and IgA antiphospholipid assays in systemic lupus erythematosus

E Akhter, Z Shums, GL Norman, W Binder… - The Journal of …, 2013 - jrheum.org
Objective. Currently, 3 antiphospholipid assays are widely used clinically [lupus
anticoagulant (LAC), anticardiolipin (aCL), and anti-ß2-glycoprotein I (anti-ß2-GPI)]. LAC is …

Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway

V Betapudi, G Lominadze, L Hsi… - Blood, The Journal …, 2013 - ashpublications.org
The antiphospholipid syndrome is characterized by thrombosis and recurrent fetal loss in
patients with antiphospholipid antibodies (APLAs). Most pathogenic APLAs are directed …

Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis

C Mineo - Current rheumatology reports, 2013 - Springer
The antiphospholipid syndrome (APS) is characterized by recurrent vascular thrombosis,
thrombocytopenia, and fetal loss occurring in the presence of antiphospholipid antibodies …