Frailty is the most problematic expression of population ageing. It is a state of vulnerability to
poor resolution of homoeostasis after a stressor event and is a consequence of cumulative …

Premature aging is a process associated with a progressive accumulation of deleterious
changes over time, an impairment of physiologic functions, and an increase in the risk of …

The frailty syndrome has recently attracted attention of the scientific community and public
health organizations as precursor and contributor of age-related conditions (particularly …

Despite the long held hypothesis that oxidant stress results in accumulated oxidative
damage to cellular macromolecules and subsequently to aging and age-related chronic …

Cross-sectional studies show that higher blood concentrations of inflammatory markers tend
to be more common in frail older people, but longitudinal evidence that these inflammatory …

BACKGROUND: Although there is no strict definition of frailty, it is generally accepted as a
state of high vulnerability for adverse health outcomes at older age. Associations between …

Background: it has been observed that a frailty index (FI) is limited by the value of 0.7.
Whether this holds in countries with higher mortality rates is not known. Objectives: to test for …

Abstract Background. The Veterans Aging Cohort Study (VACS) Index is associated with all-
cause mortality in individuals infected with human immunodeficiency virus (HIV). It is also …

All the current frailty measures count deficits. They differ chiefly in which items, and how
many, they consider. These differences are related: if a measure considers only a few items …

Chronic mood disorders have been associated with a shortened telomere, a marker of
increased mortality rate and aging, and impaired cellular immunity. However, treatment may …