It has recently been demonstrated that the genes controlling the epigenetic programmes that
are required for maintaining chromatin structure and cell identity include genes that drive …

A plethora of groundbreaking studies have demonstrated the importance of chromatin-
associated proteins and post-translational modifications of histones, proteins and DNA (so …

EZH2 or EZH1 is the catalytic subunit of the polycomb repressive complex 2 that catalyzes
methylation of histone H3 lysine 27 (H3K27). The trimethylation of H3K27 (H3K27me3) is a …

Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …

DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling
in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified …

Lysine specific demethylase 1 (LSD1), the first identified histone demethylase, plays an
important role in epigenetic regulation of gene activation and repression. The up-regulated …

Background: Emerging evidence has demonstrated that lysine-specific demethylase 1
(LSD1) has an important role in many pathological processes of cancer cells, such as …

Estrogen receptor alpha (ERα) is a ligand-activated transcription factor. Upon estrogen
stimulation, ERα recruits a number of coregulators, including both coactivators and …

The process of epithelial–mesenchymal transition (EMT) which is required for cancer cell
invasion is regulated by a family of E-box–binding transcription repressors, which include …

Recurrent prostate cancer remains a major clinical challenge. The lysine specific
demethylase-1 (LSD1/KDM1A), together with the JmjC domain-containing JMJD2A and …