Nephropathy remains a major cause of morbidity and a key determinant of mortality in
patients with type 1 or type 2 diabetes mellitus. Research is ongoing to identify biomarkers …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy
(DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a …

Sex and genetic variation influence the risk of developing diabetic nephropathy and ESRD
in patients with type 1 diabetes. We performed a genome-wide association study in a cohort …

Previously, we reported an acidification-dependent interaction of the endosomal vacuolar
H+-ATPase (V-ATPase) with cytohesin-2, a GDP/GTP exchange factor (GEF), suggesting …

The complement system functions as a part of the innate immune system. Inappropriate
activation of the complement pathways has a deleterious effect on kidneys. Recent …

Abstract The Innovative Medicines Initiative (IMI) is a large-scale public–private partnership
between the European Commission and the European Federation of Pharmaceutical …

Genome-wide association studies have proven to be highly effective at defining
relationships between single nucleotide polymorphisms (SNPs) and clinical phenotypes in …

Although the causes of diabetic nephropathy are not yet fully known, emerging evidence
suggests a role for epigenetic factors in the development of the disease. In particular …

Background A recent genome-wide association study for diabetic nephropathy in European
type 1 diabetes identified 3 candidate loci for diabetic nephropathy. In this study, we …