The genomically mosaic brain: aneuploidy and more in neural diversity and disease
DM Bushman, J Chun - Seminars in cell & developmental biology, 2013 - Elsevier
Genomically identical cells have long been assumed to comprise the human brain, with post-
genomic mechanisms giving rise to its enormous diversity, complexity, and disease …
genomic mechanisms giving rise to its enormous diversity, complexity, and disease …
Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease
G Ermak, KJA Davies - Free Radical Biology and Medicine, 2013 - Elsevier
The RCAN1 gene encodes three different protein isoforms: RCAN1-4, RCAN1-1L, and
RCAN1-1S. RCAN1-1L is the RCAN1 isoform predominantly expressed in human brains …
RCAN1-1S. RCAN1-1L is the RCAN1 isoform predominantly expressed in human brains …
High glucose promotes Aβ production by inhibiting APP degradation
Y Yang, Y Wu, S Zhang, W Song - PloS one, 2013 - journals.plos.org
Abnormal deposition of neuriticplaques is the uniqueneuropathological hallmark of
Alzheimer's disease (AD). Amyloid β protein (Aβ), the major component of plaques, is …
Alzheimer's disease (AD). Amyloid β protein (Aβ), the major component of plaques, is …
Regulation of RCAN1 translation and its role in oxidative stress‐induced apoptosis
Y Wu, W Song - The FASEB Journal, 2013 - Wiley Online Library
Abnormal expression of regulator of calcineurin 1 (RCAN1) has been implicated in
Alzheimer's disease (AD) and Down's syndrome (DS). There are two major isoforms of …
Alzheimer's disease (AD) and Down's syndrome (DS). There are two major isoforms of …
Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling
JL Shaw, KT Chang - PLoS genetics, 2013 - journals.plos.org
Post-mortem brains from Down syndrome (DS) and Alzheimer's disease (AD) patients show
an upregulation of the Down syndrome critical region 1 protein (DSCR1), but its contribution …
an upregulation of the Down syndrome critical region 1 protein (DSCR1), but its contribution …
BACE 2 degradation mediated by the macroautophagy–lysosome pathway
X Liu, Z Wang, Y Wu, J Wang… - European Journal of …, 2013 - Wiley Online Library
Neuritic plaque is the pathological hallmark in A lzheimer's disease (AD). Amyloid‐β protein
(A β), the central component of neuritic plaques, is generated from amyloid‐β precursor …
(A β), the central component of neuritic plaques, is generated from amyloid‐β precursor …
Commonality in Down and fetal alcohol syndromes
JP Solzak, Y Liang, FC Zhou… - Birth Defects Research …, 2013 - Wiley Online Library
BACKGROUND Down syndrome (DS) and Fetal Alcohol Syndrome (FAS) are two leading
causes of birth defects with phenotypes ranging from craniofacial abnormalities to cognitive …
causes of birth defects with phenotypes ranging from craniofacial abnormalities to cognitive …
CREB‐mediated Bcl‐2 expression contributes to RCAN1 protection from hydrogen peroxide‐induced neuronal death
Abstract Regulator of calcineurin 1 (RCAN1) is located on the Down syndrome critical region
(DSCR) locus in human chromosome 21. In this study, we investigated the functional role of …
(DSCR) locus in human chromosome 21. In this study, we investigated the functional role of …
Effects of the PPAR-γ agonist rosigliatazone on cognition in TG2576 mice
JD Anderson - 2013 - orca.cardiff.ac.uk
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no
cure. At the neuropathological level, AD is characterized by the presence of large numbers …
cure. At the neuropathological level, AD is characterized by the presence of large numbers …
Hydrogen peroxide-induced MAPK activation causes the increase of RCAN1 (DSCR1) protein expression
The Down syndrome critical region 1 (DSCR1) gene encodes a regulator of calcineurin 1
(RCAN1), which is overexpressed in the patients with Down syndrome. In this study, we …
(RCAN1), which is overexpressed in the patients with Down syndrome. In this study, we …