According to the traditional view, atherosclerosis results from a passive buildup of
cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune …

Background Testosterone therapy is increasingly promoted. No randomized placebo-
controlled trial has been implemented to assess the effect of testosterone therapy on …

Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …

Inflammation, which is directly regulated by interleukin-6 (IL-6) signaling, is implicated in the
etiology of several chronic diseases. Although a common, non-synonymous variant in the IL …

Myocardial infarction, a leading cause of death in the Western world, usually occurs when
the fibrous cap overlying an atherosclerotic plaque in a coronary artery ruptures. The …

The long non-coding RNA ANRIL is the best replicated genetic risk locus of coronary artery
disease (CAD) and periodontitis (PD), and is independently associated with a variety of …

Background and Purpose—Carotid ultrasound evaluation of intima-media thickness (IMT)
and plaque burden has been used for risk stratification and for evaluation of …

Objective—Current guidelines do not support the use of genetic profiles in risk assessment
of coronary heart disease (CHD). However, new single nucleotide polymorphisms …