Metformin: do we finally have an anti-aging drug?
VN Anisimov - Cell cycle, 2013 - Taylor & Francis
Studies in mammals have demonstrated that hyperglycemia and hyperinsulinemia are
important factors in aging and cancer. Inactivation of insulin/insulin-like signaling increases …
important factors in aging and cancer. Inactivation of insulin/insulin-like signaling increases …
Selective anti-cancer agents as anti-aging drugs
MV Blagosklonny - Cancer biology & therapy, 2013 - Taylor & Francis
Recent groundbreaking discoveries have revealed that IGF-1, Ras, MEK, AMPK, TSC1/2,
FOXO, PI3K, mTOR, S6K, and NFκB are involved in the aging process. This is remarkable …
FOXO, PI3K, mTOR, S6K, and NFκB are involved in the aging process. This is remarkable …
Metformin in diabetic patients with heart failure: safe and effective
IA Ekeruo, A Solhpour, H Taegtmeyer - Current cardiovascular risk reports, 2013 - Springer
Management of diabetic patients with heart failure is a complex endeavor. The initial
reluctance to use metformin in these patients has given way to a broader acceptance after …
reluctance to use metformin in these patients has given way to a broader acceptance after …
[PDF][PDF] Determinants of cardiovascular risk in diabetes beyond hyperglycemia
L Badimon, R Hernandez Vera, G Vilahur - J Cardiovasc Dis, 2013 - Citeseer
A link between diabetes and cardiovascular disease (CVD) has clearly been established.
Indeed, patients with type 2 diabetes have an increased risk of developing CVD and a worst …
Indeed, patients with type 2 diabetes have an increased risk of developing CVD and a worst …
[PDF][PDF] Altering Fate Determination of Human Bone Marrow-Derived Mesenchymal Stem Cells through Environmental and Transcriptional Cues
LB Boyette - 2013 - scholar.archive.org
Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old
age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling and …
age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling and …
[PDF][PDF] Morbid obesity and asthma: co-morbidity or causal relationship?
A Aardenburg-van Huisstede - Obesity Surgery, 2013 - scholarlypublications …
Background: Obesity is associated with respiratory symptoms and impaired pulmonary
function, which could increase the risk of complications after bariatric surgery. Aim: To …
function, which could increase the risk of complications after bariatric surgery. Aim: To …