Inflammasomes are key signalling platforms that detect pathogenic microorganisms and
sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL …

Reactive oxygen species (ROS) are a group of highly reactive chemicals containing oxygen
produced either exogenously or endogenously. ROS are related to a wide variety of human …

The NLRP3 inflammasome is an important component of the innate immune system.
However, its mechanism of activation remains largely unknown. We show that NLRP3 …

Nlrp3 inflammasome activation occurs in response to numerous agonists but the specific
mechanism by which this takes place remains unclear. All previously evaluated activators of …

NLRP3 is a key component of the macromolecular signaling complex called the
inflammasome that promotes caspase 1-dependent production of IL-1β. The adaptor ASC is …

Macrophages are present throughout the human body, constitute important immune effector
cells, and have variable roles in a great number of pathological, but also physiological …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

Aluminum-containing adjuvants are widely used in preventive vaccines against infectious
diseases and in preparations for allergy immunotherapy. The mechanism by which they …

Exposure to particulate crystals can induce oxidative stress in phagocytes, which triggers
NLRP3 inflammasome-mediated interleukin-1β secretion to initiate undesirable …

Inflammation is an innate immune response to infection or tissue damage that is designed to
limit harm to the host, but contributes significantly to ischemic brain injury following stroke …