Oxidative stress is both the cause and consequence of impaired functional homeostasis
characterizing human aging. The worsening efficiency of stress response with age …

Increasing numbers of elderly transplant recipients and a growing demand for organs from
older donors impose pressing challenges on transplantation medicine. Continuous and …

Aging affects all compartments of the immune response and has a major impact on
transplant outcome and organ quality. Although clinical trials in the aging transplant …

INTRODUCTION—Aging is characterized by progressive and broadly predictable changes
associated with increased susceptibility to many diseases. Aging is not a homogenous …

Immunosenescence is described as a decline in the normal functioning of the immune
system associated with physiologic ageing. Immunosenescence contributes to reduced …

Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem
cells are unknown. In this study, we enumerate and characterize T/NK precursors among …

Abstract Background As the European population is getting older, there is growing need in
scientific data on how to achieve healthy and successful aging. A decline in immune function …

Aging is associated with a profound reduction of the immune capacity (ie,
immunosenescence), which is manifested as increased morbidity and mortality due to …

Background Recently, a direct correlation with telomere length, proliferative potential and
telomerase activity has been found in the process of aging in peripheral blood cells. The …

Immunoparesis and a skewed serum free light chain (FLC) ratio are indicators of immune
dysfunction predictive of progression from monoclonal gammopathy of undetermined …