Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

Recent studies in mice have identified single molecules that can delay multiple diseases of
aging and extend lifespan. In theory, such molecules could prevent dozens of diseases …

The prevention or delay of the onset of age-related diseases prolongs survival and improves
quality of life while reducing the burden on the health care system. Activation of sirtuin 1 …

Mitochondrial dysfunction has gained recognition as a contributing factor in many diseases.
The kidney is a kind of organ with high energy demand, rich in mitochondria. As such …

SIRT1, an NAD‐dependent deacetylase, plays a role in regulation of autophagy. SIRT1
increases mitochondrial function and reduces oxidative stress, and has been linked to age …

Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …

Increased expression of SIRT 1 extends the lifespan of lower organisms and delays the
onset of age‐related diseases in mammals. Here, we show that SRT 2104, a synthetic small …

Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …

This review describes the key steps and methods which are used to develop enzyme assays
suitable for high-throughput screening (HTS) applications. The goals of HTS enzyme assays …

In the developing and mature brain, mitochondria act as central hubs for distinct but
interwined pathways, necessary for neural development, survival, activity, connectivity and …