Post-transcriptional coordination of immunological responses by RNA-binding proteins
P Kafasla, A Skliris, DL Kontoyiannis - Nature immunology, 2014 - nature.com
Immunological reactions are propelled by ever-changing signals that alter the translational
ability of the RNA in the cells involved. Such alterations are considered to be consequential …
ability of the RNA in the cells involved. Such alterations are considered to be consequential …
Global target mRNA specification and regulation by the RNA-binding protein ZFP36
N Mukherjee, NC Jacobs, M Hafner, EA Kennington… - Genome biology, 2014 - Springer
Background ZFP36, also known as tristetraprolin or TTP, and ELAVL1, also known as HuR,
are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich …
are two disease-relevant RNA-binding proteins (RBPs) that both interact with AU-rich …
Coordinated post-transcriptional regulation of the chemokine system: messages from CCL2
RP Panganiban, BM Vonakis, FT Ishmael… - Journal of Interferon & …, 2014 - liebertpub.com
The molecular cross-talk between epithelium and immune cells in the airway mucosa is a
key regulator of homeostatic immune surveillance and is crucially involved in the …
key regulator of homeostatic immune surveillance and is crucially involved in the …
Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation
A Cammas, BJ Sanchez, XJ Lian… - Nature …, 2014 - nature.com
HuR promotes myogenesis by stabilizing the MyoD, myogenin and p21 mRNAs during the
fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA …
fusion of muscle cells to form myotubes. Here we show that HuR, via a novel mRNA …
RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway
L Liu, E Christodoulou-Vafeiadou, JN Rao… - Molecular biology of …, 2014 - Am Soc Cell Biol
Inhibition of growth of the intestinal epithelium, a rapidly self-renewing tissue, is commonly
found in various critical disorders. The RNA-binding protein HuR is highly expressed in the …
found in various critical disorders. The RNA-binding protein HuR is highly expressed in the …
Conditional Knockout of the RNA-Binding Protein HuR in CD4+ T Cells Reveals a Gene Dosage Effect on Cytokine Production
MM Gubin, P Techasintana, JD Magee, GM Dahm… - Molecular …, 2014 - Springer
The posttranscriptional mechanisms by which RNA binding proteins (RBPs) regulate T-cell
differentiation and cytokine production in vivo remain unclear. The RBP HuR binds to labile …
differentiation and cytokine production in vivo remain unclear. The RBP HuR binds to labile …
Transcriptional and Posttranscriptional Regulation of Cytokine Gene Expression in HIV-1 Antigen-Specific CD8+ T Cells That Mediate Virus Inhibition
TL Payne, J Blackinton, A Frisbee, J Pickeral… - Journal of …, 2014 - Am Soc Microbiol
The ability of CD8+ T cells to effectively limit HIV-1 replication and block HIV-1 acquisition is
determined by the capacity to rapidly respond to HIV-1 antigens. Understanding both the …
determined by the capacity to rapidly respond to HIV-1 antigens. Understanding both the …
Mechanisms of CD8+ T Cell Mediated Virus Inhibition in HIV-1 Virus Controllers
TL Payne - 2014 - search.proquest.com
CD8+ T cells are associated with long term control of virus replication to low or undetectable
levels in a population of HIV+ therapy-naïve individuals known as virus controllers (VCs;< …
levels in a population of HIV+ therapy-naïve individuals known as virus controllers (VCs;< …