Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases

RR Kalyani, M Corriere, L Ferrucci - The lancet Diabetes & …, 2014 - thelancet.com
The term sarcopenia refers to the loss of muscle mass that occurs with ageing. On the basis
of study results showing that muscle mass is only moderately related to functional outcomes …

Male hypogonadism

S Basaria - The Lancet, 2014 - thelancet.com
Male hypogonadism is a clinical syndrome that results from failure to produce physiological
concentrations of testosterone, normal amounts of sperm, or both. Hypogonadism may arise …

Sarcopenia and androgens: a link between pathology and treatment

C Basualto-Alarcón, D Varela, J Duran… - Frontiers in …, 2014 - frontiersin.org
Sarcopenia, the age-related loss of skeletal muscle mass and function, is becoming more
prevalent as the lifespan continues to increase in most populations. As sarcopenia is highly …

Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: effects on sexual function, body composition, muscle …

G Huang, S Basaria, TG Travison, MH Ho, M Davda… - Menopause, 2014 - journals.lww.com
Objective This study aims to determine the dose-dependent effects of testosterone on sexual
function, body composition, muscle performance, and physical function in hysterectomized …

Androgen effects on skeletal muscle: implications for the development and management of frailty

MDL O'Connell, FCW Wu - Asian journal of andrology, 2014 - journals.lww.com
Androgens have potent anabolic effects on skeletal muscle and decline with age in parallel
to losses in muscle mass and strength. This loss of muscle mass and function, known as …

Serum testosterone levels and clinical outcomes in male hemodialysis patients

AK Bello, P Stenvinkel, M Lin, B Hemmelgarn… - American Journal of …, 2014 - Elsevier
Background Studies linking low serum testosterone concentration to adverse clinical
outcomes in hemodialysis patients have been relatively small. We investigated the role of …

Oxidative stress, testosterone, and cognition among Caucasian and Mexican-American men with and without Alzheimer's disease

RL Cunningham, M Singh, SE O'Bryant… - Journal of …, 2014 - content.iospress.com
Background: The use of testosterone among aging men has been increasing, but results
from studies addressing the effectiveness of testosterone replacement therapy have been …

Longitudinal and cross-sectional relationships of circulating reproductive hormone levels to self-rated health and health-related quality of life in community-dwelling …

B Hsu, RG Cumming, FM Blyth… - The Journal of …, 2014 - academic.oup.com
Context: Self-rated health and health-related quality of life are inversely associated with
increased morbidity and mortality; however, the temporal relationship with reproductive …

Multiple hormonal dysregulation as determinant of low physical performance and mobility in older persons

M Maggio, F Lauretani, F De Vita… - Current …, 2014 - ingentaconnect.com
Mobility-disability is a common condition in older individuals. Many factors, including the age-
related hormonal dysregulation, may concur to the development of disability in the elderly. In …

Biological markers in older people at risk of mobility limitations

G Lippi, F Sanchis-Gomar… - Current Pharmaceutical …, 2014 - ingentaconnect.com
Due to the progressive ageing of the worldwide population, prevention and treatment of late-
life dysfunctions, including functional decline and mobility limitations, represent leading …